CCES Unicamp

Molecular Recognition of PPAR γ by Kinase Cdk5/p25

Full Article URL: http://pubs.acs.org/doi/pdf/10.1021/acs.jpcb.5b04269

The peroxisome proliferator-activated receptor γ (PPARγ)is an important member of the nuclear receptor (NR) superfamily,
which directly binds to DNA and regulates the expression of a myriad of genes related to adipogenesis and control of several
cellular signaling, including regulation of insulin sensitization.
Pathogenically, PPARγ is involved in the treatment of type 2 diabetes, cardiovascular disease, inflammation, and cancer.

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